
Professor, Chemical and Biomolecular Engineering
mu-ping.nieh@uconn.edu | |
Phone | (860) 486-8708 |
Mailing Address | Department of Chemical & Biomolecular Engineering Engineering II, Room 204 191 Auditorium Road, Unit 3222 University of Connecticut Storrs, CT 06269-3222 |
Campus | Storrs |
Link | Research Website |
Google Scholar Link |
Brief Bio
Prof. Mu-Ping Nieh received his B.S. degree from the department of Chemical Engineering at National Taiwan University and Ph.D. degree from the departments of Chemical Engineering and Polymer Science and Engineering at University of Massachusetts, Amherst (working with Prof. David Hoagland). His graduate research focuses on investigating the conformation of solvated polymer chains in flow field using light scattering. Afterwards, he became a postdoctoral researcher employed by Pennsylvania State University (working with Prof. Sanat Kumar, now at Columbia University) but stationed at National Institute of Standards and Technology (NIST) Center for Neutron Research (NCNR) working with Dr. Charles Glinka (at NCNR) and Prof. Robert Briber (at University of Maryland). At NIST, he was involved in many researches using neutron scattering to characterize the structures of a variety of soft materials including chain conformation of highly confined polymers, spontaneous morphologies of “bicellar (bilayered micellar)” lipid mixtures and aggregation behavior of Gemini surfactants. In 2002, he joined the Neutron Program for Material Research (now Canadian Neutron Beam Centre, CNBC) of National Research Council (NRC) of Canada as a visiting fellow and later a research officer. At CNBC, he worked with Dr. John Katsaras (now at Neutron Science Directorate, ORNL) continuing to investigate the structures of lipid mixtures and biomolecules associated with lipids as functions of temperature, pressure, concentration, charge density, membrane rigidity and lipid architecture. Some of these spontaneous forming structures have many applications such as targeting theragnostic carriers (i.e., nanodiscs and nano-vesicles) and lipid substrates for aligning membrane proteins in solution (e.g., bilayered ribbons and lamellae). He also developed the first Canadian small angle neutron scattering capability on a triple-axis spectrometer using a converging multi-channel Soller collimator. In 2010, he took the faculty position at University of Connecticut as an associate professor at the Institute of Materials Science (IMS) and the department of Chemical and Biomolecular Engineering (CBE), and later, in 2013 he also joined the department of Biomedical Engineering (BME). His current research group is seeking for the fundamental understanding of thermodynamics and kinetics, which leads to uniform nanostructures of self-assemblies applicable for the use of biomedical, sensing and energy materials. The principle and knowledge obtained from the research can facilitate low-cost, mass-production processes to manufacture uniform nanoparticles.
- Structures of Uniform-sized Lipid Self-Assemblies
- Spontaneous Structural Diagrams of Bicellar Mixtures
- Bicellar Nanodiscs
- Nanovesicles
- Bilayered Ribbons
- Alignable Lamellae by Magnetic Field or Shear
- Interaction Between Nanoparticle And Cancer Cells
- Theranostic Delivery Nanocarriers
- Tumors-on-A-Chip
- Interaction between Polymers And Lipids
- Strung Lipid-Based Nanoparticles
- Instrument-Free, High-Sensitivity Biosensing
- Molecular Transfer between Nanoparticles
- Metal/Lipid Nanocomplex for Biodiagnosis
- Interaction between Fluorophores and Host Matrices
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Introduction to Chemical Engineering Thermodynamics I
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Introduction to Chemical Engineering Thermodynamics II
- 3. Nanostructural Characterization of Soft Materials
- Chung-Hao Liu, Susan Krueger, Mu-Ping Nieh*. “Synthesis of Polymer Nanoweb via a Lipid Template” ACS Macro Letters, in press
- Hanyi Duan, Zhenyang Jia, Maham Liaqat, Matthew D Mellor, Haiyan Tan, Mu-Ping Nieh, Yao Lin, Stephan Link, Christy F Landes, Jie He. “Site-Specific Chemistry on Gold Nanorods: Curvature-Guided Surface Dewetting and Supracolloidal Polymerization” ACS Nano, in press
- Vishal Kasina, Aniket Wahane, Chung-Hao Liu, Lin Yang, Mu-Ping Nieh, Frank J Slack, Raman Bahal. “Next-generation poly-L-histidine formulations for miRNA mimic delivery” Molecular Therapy-Methods & Clinical Development, 29, 271-283
- Ying Liu, Yan Xia, Armin Tahmasbi Rad, Wafa Aresh, Justin M Fang, Mu-Ping Nieh*. “Stable Discoidal Bicelles: Formulation, Characterization, and Functions” Liposomes: Methods and Protocols, 147-157
- Justin M Fang, Sayan Basu, Jak Phu, Mu-Ping Nieh*, Joseph J LoTurco. “Cellular Localization, Aggregation, and Cytotoxicity of Bicelle-Quantum Dot Nanocomposites” ACS Applied Bio Materials, 6, 566-577
- Weikang Xian, Chung-Hao Liu, Behrad Kangarlou, Shing-Yun Chang, Chao Wu, Yang Cao, Luyi Sun, Anson WK Ma, Mu-Ping Nieh, Amitesh Maiti, Andrew P Saab, Ying Li. “Effect of Diphenyl Content on Viscoelasticity of Poly(dimethyl-co-diphenyl)siloxane Melt and Network” ACS Applied Polymer Materials, 5, 1915-1925
- Chung-Hao Liu, Catherine Cheu, John G Barker, Lin Yang, Mu-Ping Nieh*. “Facile polymerization in a bicellar template to produce polymer nano-rings” Journal of Colloid and Interface Science, 630, 629-637
- Zichao Wei, Chung-Hao Liu, Qiang Luo, Srinivas Thanneeru, Alfredo M Angeles-Boza, Mu-Ping Nieh, Jie He. “Hydrophobic pockets built in polymer micelles enhance the reactivity of Cu 2+ ions” Materials Chemistry Frontiers, 7, 2038-2048
- Behrad Kangarlou, Donyeil Hoy, Haden L Scott, Sai Venkatesh Pingali, Nora Khalil, Benjamin Chung, John Katsaras, Mu-Ping Nieh*. “Water Content in Nanoparticles Determined by Small-Angle Neutron Scattering and Light Scattering” Langmuir, 39, 227-235
- Wenjian Zheng, Chung-Hao Liu, Mu-Ping Nieh, Chris J Cornelius. “Sulfonated Pentablock Copolymer Membrane Morphological Anisotropy and Its Impact on Dimensional Swelling, Proton Conductivity, and the Transport of Protons and Water” Macromolecules, 55, 9269-9281
- Zichao Wei, Chung-Hao Liu, Hanyi Duan, Qiang Luo, Margaret Huang, Srinivas Thanneeru, Mu-Ping Nieh, Jie He. “Self-assembly of gold nanoparticles grafted with amphiphilic supramolecular block copolymers” Giant, 10, 10012
- Caroline R Garcia, Armin T Rad, Farnoosh Saeedinejad, Arvind Manojkumar, Deepa Roy, Hansapani Rodrigo, Sue Anne Chew, Ziyaur Rahman, Mu-Ping Nieh, Upal Roy. “Effect of drug-to-lipid ratio on nanodisc-based tenofovir drug delivery to the brain for HIV-1 infection” Nanomedicine, 17, 959-978
- Ibtihal Alahmadi, Donyeil Hoy Jr, Armin Tahmasbi Rad, Sanyukta Patil, Anas Alahmadi, Jacob Kinnun, Haden L Scott, John Katsaras, Mu-Ping Nieh*. “Changes Experienced by Low-Concentration Lipid Bicelles as a Function of Temperature” Langmuir, 38, 4332-4340
- Justin M Fang, Sayan Basu, Mingda Li, Kuo‐Chih Shih, Jun Wang, Mircea Cotlet, Xudong Wang, Jing Zhao, TJ Mountziaris, Joseph J LoTurco, Mu‐Ping Nieh*. “Restriction‐In‐Motion of Surface Ligands Enhances Photoluminescence of Quantum Dots—Experiment and Theory” Advanced Materials Interfaces, 9, 2102079
- Shipra Malik, Vikas Kumar, Chung‐Hao Liu, Kuo‐Chih Shih, Susan Krueger, Mu‐Ping Nieh, Raman Bahal. “Head on Comparison of Self‐and Nano‐Assemblies of Gamma Peptide Nucleic Acid Amphiphiles” Advanced Functional Materials, 32, 2109552
- Francis K Masese, Dennis Ndaya, Chung-Hao Liu, Nicholas Eddy, M Daniela Morales-Acosta, Mu-Ping Nieh, Rajeswari M Kasi. “Self-assembled materials from cellulose nanocrystals conjugated with a thermotropic liquid crystalline moiety” Soft Matter, 18, 8165-8174
- Hanyi Duan, Tessa Malesky, Janet Wang, Chung-Hao Liu, Haiyan Tan, Mu-Ping Nieh, Yao Lin, Jie He. “Patchy metal nanoparticles with polymers: controllable growth and two-way self-assembly” Nanoscale, 14, 7364-7371
- Armin Tahmasbi Rad, Derek Hargrove, Leila Daneshmandi, Amanda Ramsdell, Xiuling Lu, Mu-Ping Nieh*. “Codelivery of paclitaxel and parthenolide in discoidal bicelles for a synergistic anticancer effect: structure matters” Advanced NanoBiomed Research, 2, 2100080
- Yikun Huang, Mu‐Ping Nieh, Wilfred Chen, Yu Lei. “Outer membrane vesicles (OMVs) enabled bio‐applications: A critical review” Biotechnology and bioengineering, 119, 34-47
- Chung-Hao’s paper on “Synthesis of Polymer Nanoweb via a Lipid Template” is published in the ACS Macro Letters (07/2023)
- The paper” Next-generation poly-L-histidine formulations for miRNA mimic delivery” in collaboration with Prof. Bahal is published in Molecular Therapy-Methods & Clinical Development (06/2023)
- Chung-Hao received the Pre-doctoral Travel Award from CBE in 2022-2023, congratulations! (05/2022)
- Donyeil successfully defends his dissertation. Congratulation! (04/2022)
- Chung-Hao successfully defends his dissertation. Congratulation! (03/2022)
- The paper “Hydrophobic pockets built in polymer micelles enhance the reactivity of Cu 2+ ions” in collaboration with Prof. He was published in Materials Chemistry Frontiers (03/2023)
- Justin Fang’s paper on “Cellular Localization, Aggregation, and Cytotoxicity of Bicelle-Quantum Dot Nanocomposites” is published in ACS Applied Bio Materials (02/2023)
- Chung-Hao and Behrad’s paper on “Effect of Diphenyl Content on Viscoelasticity of Poly(dimethyl-co-diphenyl)siloxane Melt and Network” is published in ACS Applied Polymer Materials (02/2023)
- Behrad’s paper on “Water Content in Nanoparticles Determined by Small-Angle Neutron Scattering and Light Scattering” is published in Langmuir (01/2023)
- Behrad successfully defend his dissertation, congratulation! (11/2022)
- Chung-Hao’s paper on “Facile polymerization in a bicellar template to produce polymer nano-rings” is published in the Journal of Colloid and Interface Science (10/2022)
- The paper “Sulfonated Pentablock Copolymer Membrane Morphological Anisotropy and Its Impact on Dimensional Swelling, Proton Conductivity, and the Transport of Protons and Water” in collaboration with Prof. Cotnrlius published in Macromolecules (10/2022)
- Justin and Luke join our group, welcome! (08/2022)
- Chung-Hao received the Samuel J. Huang Graduate Research Award in 2021-2022, congratulations! (05/2022)
- The paper “Self-Assembly of Gold Nanoparticles Grafted with Amphiphilic Supramolecular Block Copolymers” in collaboration with Prof. He was published in Giant (05/2022)
- Ibtihal’s paper on “Changes Experienced by Low-Concentration Lipid Bicelles as a Function of Temperature” is published in Langmuir (04/2022)
- The paper” Patchy Metal Nanoparticles with Polymers: Controllable Growth and Two-Way Self-Assembly” in collaboration with Prof. He published in Nanoscale (04/2022)
- The paper” Head on Comparison of Self‐and Nano‐Assemblies of Gamma Peptide Nucleic Acid Amphiphiles” in collaboration with Prof. Bahal was published in Advanced Functional Materials (01/2022)
- Justin Fang’s paper on “Restriction‐In‐Motion of Surface Ligands Enhances Photoluminescence of Quantum Dots—Experiment and Theory” is published in Advanced Materials Interfaces (01/2022)
- Dr. Armin Tahmasbi Rad’s paper on “Codelivery of Paclitaxel and Parthenolide in Discoidal Bicelles for a Synergistic Anticancer Effect: Structure Matters” is published in Advanced NanoBiomed Research (01/2022)